The relationship between somatostatin, epidermal growth factor, and steroid hormone receptors in breast cancer
- Sandoz Research Institute, Berne (Switzerland)
The somatostatin (SS) and the epidermal growth factor (EGF) receptor content have been established in 36 primary breast cancers by receptor autoradiography on adjacent tissue sections. Iodine 125 (125I)-EGF was used as radioligand for EGF receptor visualization whereas an iodinated SS-28 analogue or an octapeptide SS analogue were used to measure SS receptors. Six of 36 tumors contained SS receptors, whereas ten of the 36 tumors were shown to contain EGF receptors. None of the tumor samples containing SS receptors were simultaneously EGF receptor positive. In contrast, all SS receptor-positive tumors simultaneously contained steroid receptors. The positive correlation between SS receptors and steroid receptors as well as the negative correlation between SS receptors and EGF receptors therefore suggest that the small percentage of SS receptor-positive breast tumors are a group of differentiated breast tumors with a good prognosis. In these cases, combined hormonetherapy including SS analogs may be of potential interest.
- OSTI ID:
- 5363683
- Journal Information:
- Cancer (Philadelphia); (USA), Vol. 64:6; ISSN 0008-543X
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
GROWTH FACTORS
RECEPTORS
MAMMARY GLANDS
NEOPLASMS
SOMATOSTATIN
STEROIDS
AUTORADIOGRAPHY
EPIDERMIS
IODINE 125
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EPITHELIUM
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEMBRANE PROTEINS
MITOGENS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
SKIN
TISSUES
550201* - Biochemistry- Tracer Techniques
550901 - Pathology- Tracer Techniques