The value of immunoscintigraphy for the operative retreatment of colorectal cancer. Limitations of a new diagnostic method

Journal Article · Tue Aug 15 04:00:00 EDT 1989 · Cancer (Philadelphia); (USA)

DOI:https://doi.org/10.1002/1097-0142(19890815)64:4<830::AID-CNCR2820640412>3.0.CO;2-P· OSTI ID:5361251

Hoelting, T S; Schlag, P; Steinbaecher, M K; Kretzschmar, U; Georgi, P; Herfarth, C ^[1]

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1. Univ. of Heidelberg (Germany, F.R.)

In 42 patients with suspected recurrent colorectal cancer, results of conventional diagnostic methods were compared with those of immunoscintigraphy. In 69% of all cases, the intraoperative findings of a second-look operation served for validation, whereas in 31% close follow-up was used. Recurrent tumors were successfully localized in 83% of patients by conventional methods, whereas immunoscintigraphy was expressive in 57% of cases. Immunoscintigraphy was disappointing especially because of its low sensitivity (23%) and low predictive value (positive, 33%; negative, 37%) with regard to successful diagnosis of extrahepatic tumors compared with the results of conventional methods (77% sensitivity; positive, 94%; negative, 79%). The rate of false-positive results was relatively high with immunoscintigraphy (n = 12), 83% of which were related to extrahepatic recurrent tumors. The value of immunoscintigraphy using an immunococktail of 131-I-labeled F(ab')2 fragments of monoclonal antibodies against CEA, with Ca 19-9 as an additional diagnostic tool for early detection of recurrent colorectal cancer, must therefore be viewed critically.

• OSTI ID: 5361251
• Journal Information: Cancer (Philadelphia); (USA), Journal Name: Cancer (Philadelphia); (USA) Vol. 64:4; ISSN 0008-543X; ISSN CANCA
• Country of Publication: United States
• Language: English

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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARCINOEMBRYONIC ANTIGEN
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
GASTROINTESTINAL TRACT
GLANDS
INTERMEDIATE MASS NUCLEI
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IODINE 131
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LARGE INTESTINE
LIVER
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOIMMUNODETECTION
RADIOIMMUNOSCINTIGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RECTUM
SCINTISCANNING
SENSITIVITY ANALYSIS
TRACER TECHNIQUES