New techniques for positron emission tomography in the study of human neurological disorders
This progress report represents a summary of our performance during the two year period following initial start-up of these research activities at Michigan. Productivity has been excellent; already over 47 papers and abstracts have been published or accepted for publication from this still young program. They represent significant contributions to extending the technology of positron emission tomography in the study of human neurological disorders. Our focus is to develop more cost effective and efficient means for producing new functionally specific tracers and simpler, less expensive, means for acquiring and interpreting quantitative data. These improved processes are required for the future growth of PET as a sophisticated research tool and for the transfer of this technology to clinical use. Our approach concentrates on two separate yet related areas, radiosynthesis and data analysis. In subproject 1, Drs. Jewett and Mulholland have introduced innovative methods for improving 11C and 18F synthetic processes. In Subproject 2, Dr. Hutchins has laid the foundations for an objective analysis of the limitations and opportunities for quantifying regional PET data. In Subproject 3, Dr. Koeppe has extended rapid techniques for parameter estimation in kinetic modeling of new ligands. Finally, in Subproject 4, Dr. Frey has applied kinetic analysis to ligand tracing of the cholinergic neurotransmitter system in animal and human brain. These DOE supported studies have direct impact on clinical research here and elsewhere which is expected to improve diagnosis and treatment of degenerative neurological diseases, mental illness and brain tumors. 47 refs., 7 figs., 4 tabs.
- Research Organization:
- Michigan Univ., Ann Arbor, MI (USA). Div. of Nuclear Medicine
- Sponsoring Organization:
- DOE/ER
- DOE Contract Number:
- FG02-87ER60561
- OSTI ID:
- 5361143
- Report Number(s):
- DOE/ER/60561-T1; ON: DE90003375; TRN: 89-032138
- Country of Publication:
- United States
- Language:
- English
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New techniques for positron emission tomography in the study of human neurological disorders: Progress report, 15 June 1992--31 October 1992
New techniques for positron emission tomography in the study of human neurological disorders: Progress report, 15 June 1992--31 October 1992
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38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
CARBON 11
RADIOCHEMISTRY
FLUORINE 18
METHYL FLUORIDE
LABELLING
PARASYMPATHOLYTICS
CHEMICAL PREPARATION
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
RADIOPHARMACEUTICALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBON ISOTOPES
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOCUMENT TYPES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FLUORINATED ALIPHATIC HYDROCARBONS
FLUORINE ISOTOPES
HALOGENATED ALIPHATIC HYDROCARBONS
HOURS LIVING RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RADIOISOTOPES
SYNTHESIS
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production