A new clinical prototype tungsten-188/rhenium-188 generator to provide high levels of carrier-free rhenium-188 for radioimmunotherapy (RAIT)
- Oak Ridge National Lab., TN (United States)
- Oak Ridge National Lab., TN (United States) Tennessee Technological Univ., Cookeville, TN (United States). Dept. of Chemistry
We have developed an efficient {sup 188}W/{sup 188}Re alumina-based generator to provide carrier-free {sup 188}Re. This {sup 188}Re will be used for direct-labeling of antibodies to be used for both radioimmunodiagnosis and radioimmunotherapy. Previous studies have involved small scale generators (< 10 mCi of {sup 188}W); the goal of the present study was to fabricate and test a clinical prototype generator (170--180 mCi {sup 188}W), an amount chosen to generate 40--75 mCi of {sup 188}Re/day. In order to investigate radiolysis in the alumina-based system, columns either remained in saline at all times ( wet'') or had saline removed by an air stream after isotope elution ( dry''). Wet columns had a 40% yield after 2--3 days in saline, while dry columns had a yield of 60-75% after 2--3 days dry, indicating radiolysis may be decreasing the yield. Dry columns gave an average elution yield of 80--95%. The {sup 188}W/{sup 188}Re system has proven to be useful in providing 100--200 mCi or higher levels of carrier-free {sup 188}Re readily and consistently for labeling antibodies or other agents for therapeutic studies. 9 refs., 2 figs. (MHB)
- Research Organization:
- Oak Ridge National Lab., TN (United States)
- Sponsoring Organization:
- USDOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 5360998
- Report Number(s):
- CONF-9109176-1; ON: DE91018853
- Resource Relation:
- Conference: Annual congress of the European Association of Nuclear Medicine, Vienna (Austria), 1-5 Sep 1991
- Country of Publication:
- United States
- Language:
- English
Similar Records
Use of the Oak Ridge National Laboratory tungsten-188/rhenium-188 generator for preparation of the rhenium-188 HDD/lipiodol complex for trans-arterial liver cancer therapy
Elution of Re-188 from W-188/Re-188 generators with salts of weak acids permits efficient concentration to low volumes using a new tandem cation/anion exchange system
Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
62 RADIOLOGY AND NUCLEAR MEDICINE
RADIOISOTOPE GENERATORS
DESIGN
PERFORMANCE TESTING
RHENIUM 188
RADIOIMMUNODETECTION
RADIOIMMUNOTHERAPY
ANTIBODIES
HFIR REACTOR
ION EXCHANGE CHROMATOGRAPHY
IRRADIATION
LABELLING
NUCLEAR MEDICINE
OPTIMIZATION
RADIOLYSIS
RADIOPHARMACEUTICALS
SEPARATION PROCESSES
TUNGSTEN 186
TUNGSTEN 188
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHROMATOGRAPHY
DAYS LIVING RADIOISOTOPES
DECOMPOSITION
DIAGNOSTIC TECHNIQUES
DRUGS
ENRICHED URANIUM REACTORS
EVEN-EVEN NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
IMMUNOTHERAPY
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION REACTORS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPE PRODUCTION REACTORS
ISOTOPES
LABELLED COMPOUNDS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RHENIUM ISOTOPES
STABLE ISOTOPES
TANK TYPE REACTORS
TEST REACTORS
TESTING
THERAPY
THERMAL REACTORS
TRACER TECHNIQUES
TUNGSTEN ISOTOPES
WATER COOLED REACTORS
WATER MODERATED REACTORS
070201* - Radiation Sources- Design
Fabrication & Operation
400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production
550601 - Medicine- Unsealed Radionuclides in Diagnostics