Studies of the biotransformation and pharmacology of ketamine and its metabolites

Thesis/Dissertation · Wed Jan 01 00:00:00 EST 1986

OSTI ID:5349124

Leung, Y

The first part of the research is concerned with the synthesis, resolution and metabolism of norketamine, the primary metabolite of ketamine. Incubations of racemic norketamine, individual enantiomers of norketamine and the pseudoracemates in rat liver microsomes revealed stereoselectivity and enantiomeric interactions during the metabolism of norketamine. The second part of the research describes the synthesis of 6-OH-norketamine, the major secondary metabolite of ketamine, and reports on its pharmacological activity and cerebral distribution in the rat. Primary deuterium isotope effects associated with the metabolism and pharmacological activity of ketamine-N-CD/sub 3/ were examined in the third part of this research. The last part of the research deals with the effect of diazepam on the metabolic transformation of ketamine to norketamine in the rat. The fractions of ketamine metabolized to norketamine were found not to be different in the presence or the absence of diazepam.

• Research Organization: Washington Univ., Seattle (USA)
• OSTI ID: 5349124
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANESTHETICS
CHEMICAL PREPARATION
METABOLISM
TRANQUILIZERS
BIOCHEMICAL REACTION KINETICS
BRAIN
DEUTERIUM
ISOTOPE EFFECTS
LIVER
METABOLITES
MICROSOMES
PHARMACOLOGY
RATS
TRACER TECHNIQUES
ANIMALS
BODY
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DIGESTIVE SYSTEM
DRUGS
GLANDS
HYDROGEN ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
MAMMALS
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANOIDS
ORGANS
PSYCHOTROPIC DRUGS
REACTION KINETICS
RODENTS
STABLE ISOTOPES
SYNTHESIS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques