Effect of intoxication with vanadium compounds on copper metabolism in the rat
Vanadium is required in comparatively small quantities for normal growth and differentiation in all organisms. Whether the element is essential and what its precise function is remains difficult to ascertain because the reported evidence is inconclusive. Man's activities in petroleum and metallurgical refining have magnified naturally high concentrations of the metal in certain crude oils and ores. The adverse effects of human exposure to the combustion products of vanadium-bearing residual oils and to fumes and dusts in metallurgical refining have stimulated interest in vanadium toxicology. The mechanisms by which vanadium exerts its toxic effects are poorly understood, but interference with the normal kinetics and macromolecular binding of the body's other essential metals, such as Zn, Ca, Mg, Fe, Cu may play a significant role. The purpose of the present study was to determine the influence of intoxication with vanadium compounds (NaVO/sub 3/ and VOSO/sub 4/) on the intestinal transport of copper. Serum levels of copper and ceruloplasmin and copper content in the liver were also assayed.
- Research Organization:
- Institute of Biopharmacy, Warsaw, Poland
- OSTI ID:
- 5348460
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 40:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CERULOPLASMIN
BLOOD CHEMISTRY
COPPER COMPOUNDS
METABOLISM
VANADIUM COMPOUNDS
BIOLOGICAL EFFECTS
RATS
SODIUM COMPOUNDS
VANADATES
VANADIUM SULFATES
ALKALI METAL COMPOUNDS
ANIMALS
COMPLEXES
COPPER COMPLEXES
GLOBULINS
GLOBULINS-ALPHA
MAMMALS
METALLOPROTEINS
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PROTEINS
RODENTS
SULFATES
SULFUR COMPOUNDS
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology