Effect of glucose-insulin-potassium infusion on thallium myocardial clearance

Journal Article · Fri Jul 01 00:00:00 EDT 1983 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.68.1.203· OSTI ID:5346822

Wilson, R A; Okada, R D; Strauss, H W; Pohost, G M

Factors influencing the rate of /sup 201/Tl clearance from the myocardium have not been clearly defined. This study determined the effect of an intravenous infusion of glucose-insulin-potassium (GIK) on the net /sup 201/Tl clearance rates from myocardium with and without initial /sup 201/Tl loading. Anesthetized open-chest dogs underwent 5 min of left anterior descending coronary artery occlusion and intravenous /sup 201/Tl was injected and the occlusion released 5 min later. Thirty minutes after /sup 201/Tl injection, 30 ml of either GIK (nine dogs) or saline (five dogs) was infused intravenously. The clearance rates of /sup 201/Tl from the anterior wall (without initial /sup 201/Tl loading) and from the posterior wall (with initial /sup 201/Tl loading) were monitored with miniaturized cadmium telluride detectors placed on the myocardium. Calculation of net myocardial clearance rates was performed by linear regression analysis from serial 1 min counts. Compared with saline infusion, GIK increased the net clearance of /sup 201/Tl from both myocardial regions with and without initial loading. The most marked change induced by GIK infusion was in the myocardial region without initial /sup 201/Tl loading; a net increase in /sup 201/Tl activity (72 +/- 42 cpm/30 min) was converted into a net loss (-594 +/- 228 cpm/30 min). There was no significant change in /sup 201/Tl clearance after the saline infusion. Heart rate, aortic and left atrial pressure, sonomicrometer-measured transmural myocardial wall thickness, microsphere-determined myocardial blood flow, and blood glucose and potassium concentrations did not change significantly during GIK or saline infusions. Thus, GIK infusion appears to increase net /sup 201/Tl clearance from myocardial zones with and without initial /sup 201/Tl loading.

• Research Organization: Nuclear Medicine Division, Massachusetts General Hospital, Boston
• OSTI ID: 5346822
• Journal Information: Circulation; (United States), Vol. 68:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MYOCARDIUM
RADIONUCLIDE KINETICS
THALLIUM 201
CLEARANCE
DOGS
GLUCOSE
INFUSION
INSULIN
POTASSIUM
RESPONSE MODIFYING FACTORS
ALDEHYDES
ALKALI METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
HEART
HEAVY NUCLEI
HEXOSES
HORMONES
INTAKE
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
METALS
MONOSACCHARIDES
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
RADIOISOTOPES
SACCHARIDES
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
VERTEBRATES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)