Emerging pathogens: Dynamics, mutation and drug resistance

Technical Report · Wed Oct 01 00:00:00 EDT 1997

DOI:https://doi.org/10.2172/534529· OSTI ID:534529

Perelson, A S; Goldstein, B; Korber, B T ^[1]

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1. and others

This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The objectives of this project were to develop models of the spread of pathogens, such as HIV-1 and influenza, in humans, and then to use the models to address the possibility of designing appropriate drug therapies that may limit the ability of the pathogen to escape treatment by mutating into a drug resistant form. We have developed a model of drug-resistance to amantidine and rimantadine, the two major antiviral drugs used to treat influenza, and have used the model to suggest treatment strategies during an epidemic.

• Research Organization: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
• Sponsoring Organization: USDOE Assistant Secretary for Human Resources and Administration, Washington, DC (United States)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 534529
• Report Number(s): LA-UR-97-3505; ON: DE98000090; TRN: 97:005410
• Resource Relation: Other Information: PBD: [1997]
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
PATHOGENS
THERAPY
DRUGS
INFLUENZA
AIDS VIRUS
MUTATIONS
INFECTIOUS DISEASES