Metabolism of guanido-labeled (C-14)arginine in rats, mice, and man
(6-/sup 14/C)arginine, injected intraperitoneally into normal rats, was cleared from the plasma with biphasic decay kinetics. Urinary excretion was efficient (32% of the 25-..mu..Ci dose within the first 24 h) with no preferential tissue retention. In mice, the effective duration of the radiotracer's availability for protein biosynthesis was less than 30 min. When the tracer was administered iv to patients with multiple myeloma, it was similarly cleared from the plasma with biphasic kinetics, and was excreted rapidly in the urine (22% of the dose within the first 24 h). In patients, the guanido-tagged arginine labeled only tumor M component, and the labeling was most intense in patients who had far advanced disease. Estimated radiation dose to humans from a 100-..mu..Ci injection was 10 mrads. These studies demonstrate the feasibility of in vivo labeling with (6-/sup 14/C)arginine, with minimal radiation hazard, thus providing a simple, sensitive, and specific method for monitoring the synthesis of the plasmacytoma M component in patients with multiple myeloma.
- Research Organization:
- Johns Hopkins Univ., Baltimore, MD
- OSTI ID:
- 5343386
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 21:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ARGININE
METABOLISM
CARBON 14
TRACER TECHNIQUES
BIOCHEMICAL REACTION KINETICS
BIOSYNTHESIS
BLOOD-PLASMA CLEARANCE
DIAGNOSIS
EXCRETION
EXPERIMENTAL DATA
INTRAPERITONEAL INJECTION
ISOLATED VALUES
LABELLED COMPOUNDS
MICE
PATIENTS
RADIATION DOSES
RATS
RETENTION
URINE
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBON ISOTOPES
CARBOXYLIC ACIDS
CLEARANCE
DATA
DATA FORMS
DOSES
EVEN-EVEN NUCLEI
INFORMATION
INJECTION
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
MAMMALS
MATERIALS
NUCLEI
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
REACTION KINETICS
RODENTS
SYNTHESIS
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES
550501* - Metabolism- Tracer Techniques
550601 - Medicine- Unsealed Radionuclides in Diagnostics