Reaction of the hydrated electron with amino acids, peptides, and proteins in aqueous solutions. Tryptophyl peptides
The reaction rate constants of e/sub aq//sup -/ with glycyl-tryptophan, glycyl-glycyl-tryptophan, and glycyl-tryptophyl-glycine were determined. The rate constant of each peptide was found to be pH dependent. This is attributed to the overall charge of the molecule. It was found that the increase of carbonyl groups increases the e/sub aq//sup /sup -// reactivity toward the peptide. The transient absorbing spectra resulting from the reaction of e/sub aq//sup /sup -// with tryptophyl peptides showed the presence of an electron adduct on the indole and a deaminated radical. The yield of the last species was found to be on the order of 40 percent. The OH reaction with glycyl-tryptophan was also investigated. It was shown that its reaction rate constant and the transient produced are similar to that observed with tryptophan.
- Research Organization:
- Nuclear Research Centre-Negev, Beersheba, Israel
- OSTI ID:
- 5340933
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 72:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Pulse radiolysis studies of electron transfer reaction in molecules of biological interest. I. The reduction of a disulfide bridge by peptide radicals
Pulse radiolysis studies of electron-transfer reaction in molecules of biological interest. II. The reduction of Cu(II)-peptide complexes
Related Subjects
400600 -- Radiation Chemistry
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ADDUCTS
AMINO ACIDS
AQUEOUS SOLUTIONS
AZOLES
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DISPERSIONS
ELECTRONS
ELEMENTARY PARTICLES
FERMIONS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
LEPTONS
MIXTURES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PEPTIDES
PH VALUE
PROTEINS
PYRROLES
SOLUTIONS
SOLVATED ELECTRONS
SPECTRA
TRYPTOPHAN