Preliminary results using twice-a-day fractionation in the radiotherapeutic management of advanced cancers of the head and neck

Journal Article · Thu Dec 01 04:00:00 EST 1977 · Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.129.6.1091· OSTI ID:5340116

Jampolis, S; Pipard, G; Horiot, J C; Bolla, M; Le Dorze, C

Twenty-four cases of advanced T4 cancers of the head and neck were treated using a twice-a-day treatment fractionation delivering a 1,200 rad weekly tumor dose and 7,000 rad total tumor dose in 5/sup 1///sub 2/ to 6 weeks. Acute normal mucosal reactions and skin reactions were plotted weekly and corresponded to reactions observed when delivering 1,000 rad per week in five treatment sessions. Chronic problems have been limited to severe neck fibrosis appearing in three of five patients who underwent a planned neck dissection 6 weeks after the completion of radiotherapy. Local control was observed in 14 of 23 patients (61%) and regional control in 22 of 23 patients (96%).

• Research Organization: Centre Georges-Francois Leclerc, Dijon, France
• OSTI ID: 5340116
• Journal Information: Am. J. Roentgenol.; (United States), Journal Name: Am. J. Roentgenol.; (United States) Vol. 129:6; ISSN AJROA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
FIBROSIS
FRACTIONATED IRRADIATION
HEAD
IRRADIATION
MEDICINE
NECK
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SKIN
THERAPY