Neurotoxic metabolites of ''commercial hexane'' in the urine of shoe factory workers
Urinary metabolites were tested in 41 shoe-factory workers exposed to a mixture of 10 solvents among which ''commercial hexane'' was the prevailing component. Cyclohexanol, 2-methyl-2-pentanol, 3-methyl-2-pentanol, and trichloroethanol were determined in connection with exposure to cyclohexane, 2-methylpentane, 3-methylpentane, and trichloroethylene, respectively. 2-Hexanol, 2,5-hexanedione, 2,5-dimethylfuran, and gamma-valerolactone were all determined in connection with n-hexane exposure only. 2,5-Hexanedione was the principal n-hexane metabolite found in the workers' urine. This finding of the experimentally proven neurotoxin 2,5-hexanedione in the urine of shoe-factory workers exposed to ''commercial hexane'' is consistent with the idea that this compound is responsible for the development of neuropathy in this group of individuals.
- Research Organization:
- Institute of Occupational Medicine, University of Padua-Verona, Italy
- OSTI ID:
- 5335840
- Journal Information:
- Clin. Toxicol.; (United States), Journal Name: Clin. Toxicol.; (United States) Vol. 18:12; ISSN CTOXA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKANES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
DISEASES
EPIDEMIOLOGY
HAZARDS
HEALTH HAZARDS
HEXANE
HYDROCARBONS
MANUFACTURERS
MATERIALS
NERVOUS SYSTEM DISEASES
OCCUPATIONAL SAFETY
ORGANIC COMPOUNDS
ORGANIC SOLVENTS
PERSONNEL
SAFETY
SOLVENTS
TEXTILES
TOXICITY
URINE
WASTES