Predicting the carcinogenic potential of environmental nitropyrenes

Journal Article · Thu Jan 01 04:00:00 EST 1987 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2850100205· OSTI ID:5335520

Rosenkranz, H S

Nitrated polycyclic aromatic hydrocarbons (nitroarenes) constitute a large group of anthrapogenic environmental contaminants. Some members of the group are mutagenic and genotoxic in a wide spectrum of systems while others are either mutagenic only in Salmonella typhimurium or devoid of activity altogether. Additionally, some nitroarenes are uniformly carcinogenic in rodents while others are not. In view of the logistic and economic problems involved in preparing large quantities of individual nitroarenes in pure (>99.5%) form and assaying them for carcinogenicity in animals. The authors have analyzed the results that nitropyrenes and related chemicals yield in short-term tests by CPBS, the Carcinogen Prediction, and Battery Selection method, and demonstrate that CPBS classifies them correctly with respect to carcinogenicity.

• Research Organization: Case Western Reserve Univ., Cleveland, OH
• OSTI ID: 5335520
• Journal Information: Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 10:2; ISSN ENMUD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
BACTERIA
CARCINOGEN SCREENING
CARCINOGENESIS
MAMMALS
MICE
MICROORGANISMS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
POLLUTION
POLYCYCLIC NITRO COMPOUNDS
RATS
RISK ASSESSMENT
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
VERTEBRATES