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Comparative histological studies of the tunable dye (at 577 nm) laser and argon laser: the specific vascular effects of the dye laser

Journal Article · · J. Invest. Dermatol.; (United States)
; ; ; ; ; ;
This study compares the histological changes occurring after argon laser and dye laser (operating at 577 nm) treatment of normal human skin. The initial effect of the argon laser is a diffuse nonspecific epidermal and upper dermal necrosis with subsequent cell death and a neutrophilic response at 48 hr. These changes occur at 15 joules/cm2 and their extent closely correlates with the energy applied. In sharp contrast, the immediate effect of the dye laser is erythrocyte aggregation, vessel rupture, and hemorrhage. At 48 hr, there is a pattern of acute vasculitis in the upper dermis and a prominent perivascular neutrophilic response in the mid-dermis. Focal epidermal necrosis does occur but is relatively minimal, while skin appendages and collagen are preserved. The energy to produce these alterations is relatively small, approximately 3 J/cm2. Thus, the dye laser at 577 nm can selectively damage the cutaneous vascular plexus and may provide a basis for treatment of cutaneous vascular lesions.
OSTI ID:
5334981
Journal Information:
J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 77:3; ISSN JIDEA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560400* -- Other Environmental Pollutant Effects
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
DYE LASERS
ELECTROMAGNETIC RADIATION
ERYTHROCYTES
GAS LASERS
HEMORRHAGE
LASER RADIATION
LASERS
LIQUID LASERS
MATERIALS
NECROSIS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIATIONS
SENSITIVITY
SIDE EFFECTS
SKIN
SYMPTOMS