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Intramolecular hydrogen bonding as reflected in the deuterium isotope effects on carbon-13 chemical shifts. Correlation with hydrogen bond energies

Journal Article · · J. Am. Chem. Soc.; (United States)
DOI:https://doi.org/10.1021/ja00268a003· OSTI ID:5333839
The carbon-13 resonances of atoms bearing phenolic or enolic hydroxyl groups, that are engaged in intramolecular hydrogen bonds, experience large (/sup 2/..delta.. may exceed 1 ppm) upfield deuterium isotope effects. The magnitude of the two-bond isotope effect, /sup 2/..delta.., correlates with the hydrogen bond energy as obtained from the hydroxyl proton chemical shift. In the conjugated systems investigated in this work, the isotope effects extend over several (up to six) chemical bonds. The signs and magnitudes of the long-range isotope effects are related to molecular structure.
Research Organization:
Hercules Inc., Wilmington, DE
OSTI ID:
5333839
Journal Information:
J. Am. Chem. Soc.; (United States), Journal Name: J. Am. Chem. Soc.; (United States) Vol. 108:8; ISSN JACSA
Country of Publication:
United States
Language:
English