Application of stoichiometry and energetics in modeling and control of fermentation processes
Thesis/Dissertation
·
OSTI ID:5333232
Most bioreactors have to be controlled closely to maintain optimum operating conditions. The effectiveness of controls depends on the accuracy of bioreactor state estimation. Despite recent progress in sensor technology, the monitoring of the bioreactor state is still difficult. Problems in bioreactor monitoring can be solved by using stoichiometry, energetics, or kinetic models. This thesis includes the analysis of fermentation stoichiometry, modeling of growth energetics in energy-sufficient cultures, and a kinetic model for glutamic acid fermentation. Stoichiometric constraints can be derived from mass balances by using the macroscopic and the pathway methods. The effectiveness of existing methods is systematically analyzed. A model for the energy-sufficient chemostat culture growth, using an innovative concept of energy surplus, is proposed and verified. The model provides a quantitative understanding of the growth energetics of energy-sufficient cultures. A kinetic model is proposed for glutamic acid fermentation by using the energy-surplus concept.
- Research Organization:
- Drexel Univ., Philadelphia, PA (USA)
- OSTI ID:
- 5333232
- Country of Publication:
- United States
- Language:
- English
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