Effects of cadmium on ribosomal protein synthesis in rat liver

Journal Article · Tue Feb 01 04:00:00 EST 1977 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(77)90008-1· OSTI ID:5332931

Norton, K B; Kench, J E

Cadmium administered to rats at a dosage level of 2 mg Cd/kg body weight per week for 2 to 3 weeks caused inhibition of protein synthesis in vitro by isolated ribosomes in an amino-acid-incorporating system prepared from liver. The rate of translation on treated ribosomes was lowered by 25% when normal pH 5 enzyme was used in the assay system, and by 35% when cell sap was used as an enzyme source. The rate of incorporation was further diminished when enzymes were prepared from Cd-poisoned animals. Significant quantities of cadmium were found to be present in purified ribosomes and enzyme preparations, indicating attachment of cadmium to isolated ribosomes and proteins.

• Research Organization: Univ. of Cape Town Medical School, Observatory
• OSTI ID: 5332931
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 13:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BODY
CADMIUM
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CHEMICAL ANALYSIS
DIGESTIVE SYSTEM
ELEMENTS
ENZYME INHIBITORS
ENZYMES
GLANDS
IN VITRO
INHIBITION
LIVER
MAMMALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PH VALUE
PROTEINS
QUANTITATIVE CHEMICAL ANALYSIS
RATS
RIBOSOMES
RODENTS
SYNTHESIS
VERTEBRATES
WEIGHT