Criteria for the selection of radionuclides for tumor radioimmunotherapy

Conference · Tue Jan 01 04:00:00 EST 1991

OSTI ID:5332217

Srivastava, S C; Mausner, L F; Mease, R C

The potential of utilizing monoclonal antibodies as carriers of radionuclides for the selective destruction of tumors (radioimmunotherapy, RIT) has stimulated much research activity. From dosimetric and other considerations, the choice of radiolabel is an important factor that needs to be optimized for maximum effectiveness of RIT. This paper reviews and assesses a number of present and future radionuclides that are particularly suitable for RIT based on the various physical, chemical, and biological considerations. Intermediate to high-energy beta emitters' (with and without gamma photons in their emission) are emphasized since they possess a number of advantages over alpha and Auger emitters. Factors relating to the production and availability of candidate radiometals as well as their stable chemical attachment to monoclonal antibodies are discussed. 34 refs., 4 tabs.

• Research Organization: Brookhaven National Lab., Upton, NY (United States)
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5332217
• Report Number(s): BNL-46589; CONF-9109287--1; ON: DE92000485
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COMPARATIVE EVALUATIONS
COPPER 67
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENERGY TRANSFER
EVALUATION
EVEN-ODD NUCLEI
GOLD 199
GOLD ISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
IMMUNOTHERAPY
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE 131
IODINE ISOTOPES
IRRADIATION REACTORS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE PRODUCTION REACTORS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LET
MEDICINE
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
OPTIMIZATION
PRODUCTION
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
REACTORS
RHENIUM 186
RHENIUM ISOTOPES
RHODIUM 105
RHODIUM ISOTOPES
SAMARIUM 153
SAMARIUM ISOTOPES
SCANDIUM 47
SCANDIUM ISOTOPES
SECONDS LIVING RADIOISO
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
YEARS LIVING RADIOI
YEARS LIVING RADIOISOTOPES
YTTRIUM 90
YTTRIUM ISOTOPES