Effect of time between x-irradiation and chemotherapy on the growth of three solid mouse tumors. V. Bleomycin
Experiments have been carried out to determine the effect of different time intervals between the administration of x-radiation (1200 rad) and bleomycin (20 mg/kg) on the growth delay produced in three mouse tumors. The tumors used were the EMT6 tumor in BALB/c mice and the KHT and RIF-1 sarcomas in C3H mice. All tumors were grown intramuscularly in the gastrocnemius muscle and treatment was carried out at a mean tumor weight of 450 mg. Time to reach 2X (for KHT) or 4X (for EMT6 and RIF-1) treatment volume was used as the endpoint of response. The drug was administered by the intraperitoneal route either 24, 6, or 2 hr before radiation, immediately before the start of radiation, or 3, 6, or 24 hr after radiation. All irradiations were carried out in unanesthetized mice. For a single administration at this dose level, bleomycin alone did not produce a significant growth delay in any of the tumors. In the RIF-1 tumor, growth delays following combination treatments were equal to the addition of the single agent growth delays. In two experiments with EMT6, contrary results were obtained, one producing longer delays following combination treatments than predicted and the other producing shorter delays. This is apparently due to the variability in the growth delay after treatment with radiation alone for this tumor. For the KHT tumor, only small differences from the addition of single agent delays were seen.
- Research Organization:
- Stanford Univ. School of Medicine, CA
- OSTI ID:
- 5332191
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 5:9; Conference: Conference on combined modalities: chemotherapy/radiotherapy. Part 2, Hilton Head Island, SC, USA, 15 Nov 1978
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
BLEOMYCIN
RADIOSENSITIVITY EFFECTS
GROWTH
BIOLOGICAL RADIATION EFFECTS
MICE
NEOPLASMS
X RADIATION
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
ISOLATED VALUES
TIME DEPENDENCE
VOLUME
ANIMALS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
DATA
DATA FORMS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
INFORMATION
IONIZING RADIATIONS
MAMMALS
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)