Increased uptake of 18F-fluorodeoxyglucose in postischemic myocardium of patients with exercise-induced angina

Journal Article · Tue Jul 01 04:00:00 EDT 1986 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.74.1.81· OSTI ID:5330931

Camici, P; Araujo, L I; Spinks, T; Lammertsma, A A; Kaski, J C; Shea, M J; Selwyn, A P; Jones, T; Maseri, A

Regional myocardial perfusion and exogenous glucose uptake were assessed with rubidium-82 (82Rb) and 18F-2-fluoro-2-deoxyglucose (FDG) in 10 normal volunteers and 12 patients with coronary artery disease and stable angina pectoris by means of positron emission tomography. In patients at rest, the myocardial uptake of /sup 82/Rb and FDG did not differ significantly from that measured in normal subjects. The exercise test performed within the positron camera in eight patients produced typical chest pain and ischemic electrocardiographic changes in all. In each of the eight patients a region of reduced cation uptake was demonstrated in the /sup 82/Rb scan recorded at peak exercise, after which uptake of /sup 82/Rb returned to the control value 5 to 14 min after the end of the exercise. In these patients, FDG was injected in the recovery phase when all the variables that were altered during exercise, including regional myocardial /sup 82/Rb uptake, had returned to control values. In all but one patient, FDG accumulation in the regions of reduced /sup 82/Rb uptake during exercise was significantly higher than that in the nonischemic regions, i.e., the ones with a normal increment of /sup 82/Rb uptake on exercise. In the nonischemic areas, FDG uptake was not significantly different from that found in normal subjects after exercise. In conclusion, myocardial glucose transport and phosphorylation seem to be enhanced in the postischemic myocardium of patients with exercise-induced ischemia.

• Research Organization: Hammersmith Hospital, London, England
• OSTI ID: 5330931
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 1; ISSN CIRCA
• Country of Publication: United States
• Language: English

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BODY
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