Effects of dimethylformamide (DMF) on coagulation and platelet activity

Journal Article · Sat Mar 01 00:00:00 EST 1986 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1986.9937415· OSTI ID:5324131

Imbriani, M; Ghittori, S; Prestinoni, A; Longoni, P; Cascone, G; Gamba, G

The effects of dimethylformamide (DMF) on hemostatic functions, especially on platelet activity, were examined both in vitro and in vivo in 15 workers exposed to DMF (27 mg/m3, median value). Twenty-eight control subjects who were not exposed to DMF, but comparable for age, anthropometric data, and smoking habits, were also studied. Workers exposed to DMF showed a decrease in the number of platelets and had longer coagulation times, probably due to a change caused by DMF on the membrane receptor of platelets and on the phospholipid components of the clotting system.

• Research Organization: Univ. of Pavia, Italy
• OSTI ID: 5324131
• Journal Information: Arch. Environ. Health; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FORMAMIDE
TOXICITY
BLOOD COAGULATION
BLOOD PLATELETS
COLLAGEN
INHIBITION
LIVER
OCCUPATIONAL EXPOSURE
PERSONNEL
AMIDES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
GLANDS
MATERIALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROTEINS
SCLEROPROTEINS
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)