AFRRI reports. First Quarter, January-March 1991. Scientific report

Technical Report · Mon Apr 01 04:00:00 EST 1991

OSTI ID:5318663

Ionizing radiation reduces the host's defenses to infection (1) and enhances its susceptibility to systemic infection due to endogenous and exogenous organisms. Klebsiella pneumoniae is one of the most frequent causes of gram-negative bacteremia, and is especially prevalent in immunocompromised patients. Therapy for severe systemic infection due to gram-negative bacteria generally involves the use of aminoglycosides in combination with beta lactam antibiotics. However, several recently developed quinolone compounds have exhibited high in vitro bactericidal activity against most gram negative bacteria. including K. pneumoniae. In this study, the authors evaluated the efficacy of oral therapy with several quinolones in a model of experimental septicemia due to orally ingested K pneumoniae in irradiated mice.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD (United States)
• OSTI ID: 5318663
• Report Number(s): AD-A-235899/2/XAB; AFRRI-SR--91-1
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
AROMATICS
AZAARENES
AZINES
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHEMOTHERAPY
DISEASES
DRUGS
HETEROCYCLIC COMPOUNDS
INFECTIOUS DISEASES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
QUINOLINES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RETICULOENDOTHELIAL SYSTEM
RODENTS
SEPTICEMIA
THERAPY
TISSUES
VERTEBRATES