Maternal and perinatal risk factors for childhood leukemia

Journal Article · Mon Jul 15 00:00:00 EDT 1991 · Cancer Research; (United States)

OSTI ID:5317819

Zack, M; Adami, H O; Ericson, A ^[1]

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1. Centers for Disease Control, Atlanta, GA (USA)

This report describes an exploratory population-based study of maternal and perinatal risk factors for childhood leukemia in Sweden. The Swedish National Cancer Registry ascertained 411 cases in successive birth cohorts from 1973 through 1984 recorded in the Swedish Medical Birth Registry. Using the latter, we matched five controls without cancer to each case by sex and month and year of birth. Mothers of children with leukemia were more likely to have been exposed to nitrous oxide anesthesia during delivery than mothers of controls (odds ratio (OR) = 1.3; 95% confidence interval (CI) = 1.0, 1.6). Children with leukemia were more likely than controls to have Down's syndrome (OR = 32.5; 95% CI = 7.3, 144.0) or cleft lip or cleft palate (OR = 5.0; 95% CI = 1.0, 24.8); to have had a diagnosis associated with difficult labor but unspecified complications (OR = 4.5; 95% CI = 1.1, 18.2) or with other conditions of the fetus or newborn (OR = 1.5; 95% CI = 1.1, 2.1), specifically, uncomplicated physiological jaundice (OR = 1.9; 95% CI = 1.2, 2.9); or to have received supplemental oxygen (OR = 2.6; 95% CI = 1.3, 1.3, 4.9). Because multiple potential risk factors were analyzed in this study, future studies need to check these findings. The authors did not confirm the previously reported higher risks for childhood leukemia associated with being male, having a high birth weight, or being born to a woman of advanced maternal age.

• OSTI ID: 5317819
• Journal Information: Cancer Research; (United States), Vol. 51:14; ISSN 0008-5472
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LEUKEMIA
ETIOLOGY
NITROUS OXIDE
BIOLOGICAL EFFECTS
CHILDREN
OXYGEN
PREGNANCY
WOMEN
AGE GROUPS
ANIMALS
CHALCOGENIDES
DISEASES
ELEMENTS
FEMALES
IMMUNE SYSTEM DISEASES
MAMMALS
MAN
NEOPLASMS
NITROGEN COMPOUNDS
NITROGEN OXIDES
NONMETALS
OXIDES
OXYGEN COMPOUNDS
PRIMATES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology