Dietary fat level and alcohol-induced pancreatic injury
Conference
·
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5316668
Effects of dietary fat levels on alcohol-induced pancreatic injury were studied in a rat model which achieves sustained blood alcohol levels and maximal nutritional control. A diet containing 5, 25, or 35% of fat (corn oil; % total calories) and either ethanol or isocaloric dextrose were intragastrically infused in male Wistar rats for 30-120 days. Following intoxication, the pancreatic pathology was examined light-microscopically. None of pair-fed controls showed abnormal pancreas histology. These results indicate potentiation of alcohol-induced pancreatic injury. Particularly higher incidence of chronic interstitial pancreatitis with increased dietary fat.
- Research Organization:
- VA Medical Center, Martinez, CA
- OSTI ID:
- 5316668
- Report Number(s):
- CONF-8604222-
- Conference Information:
- Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550900 -- Pathology
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
BIOLOGICAL MODELS
BODY
DIET
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
ENDOCRINE GLANDS
ETHANOL
FATS
GLANDS
HYDROXY COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PANCREAS
PATHOLOGICAL CHANGES
RATS
RODENTS
TOXICITY
VERTEBRATES
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
BIOLOGICAL MODELS
BODY
DIET
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
ENDOCRINE GLANDS
ETHANOL
FATS
GLANDS
HYDROXY COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PANCREAS
PATHOLOGICAL CHANGES
RATS
RODENTS
TOXICITY
VERTEBRATES