Radioimmunoassay of paralytic shellfish toxins in clams and mussels

Journal Article · Sat Aug 01 04:00:00 EDT 1987 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01689416· OSTI ID:5315508

Yang, G C; Imagire, S J; Yasaei, P; Ragelis, E P; Park, D L; Page, S W; Carlson, R E; Guire, P E

Shellfish contaminated with paralytic shellfish poisons (PSP) compromise human health. The threat of this contamination results in enormous economic losses in the recreational and commercial exploitation of shellfish resources in the affected areas. Most states deal with the PSP problem either by prohibiting the collection of shellfish during certain time periods or by instituting monitoring programs. The only recognized method of analysis for PSP that is currently and routinely used in monitoring programs is the time-of-death mouse bioassay. Several attempts to develop simple and highly specific biochemical assays for the detection and quantitation of the PSP toxins have been reported. More recently, much improved immunoassays have been developed. To evaluate the validity and usefulness of the immunoassay for the determination of PSP toxins, the authors have used extracts of shellfish gathered from Maine and Connecticut to compare the results of the mouse bioassay and HPLC methods with the radioimmunoassay developed previously.

• Research Organization: Food and Drug Administration, Washington, DC (USA)
• OSTI ID: 5315508
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 39:2; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIGENS
AQUATIC ORGANISMS
CHROMATOGRAPHY
CLAMS
IMMUNOASSAY
IMMUNOLOGY
INVERTEBRATES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
MATERIALS
MOLLUSCS
MUSSELS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
SEPARATION PROCESSES
TOXIC MATERIALS
TOXINS
TRACER TECHNIQUES