Deposition of radon progeny in nonhuman primate nasal airways

Conference · Mon Dec 31 23:00:00 EST 1990

OSTI ID:5314824

Yeh, H C; Cheng, Y S; Su, Y F ^[1]; Morgan, K T ^[2]

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1. Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
2. Chemical Industry Inst. of Toxicology, Research Triangle Park, NC (United States)

Information on aerosol deposition patterns in the human respiratory tract is needed to improve health risk estimates for exposure to airborne radon progeny. To investigate this, deposition of {sup 220}Rn progeny in Rhesus monkey nasal casts was examined. A substantial fraction of the inhaled ultrafine particles are deposited in the nasal cast. Deposition efficiency increases with decreasing particle size, reaching a maximum value of 80% for particles 1.7 nm in diameter. Breathing flow rate has a minimal effect on deposition efficiency. Deposition efficiencies for particles smaller than 100 nm in diameter are similar for monkey and human nasal casts. Equations based on turbulent diffusion can be fitted to these data for either inspirational or expirational flow. These mathematical expressions will be useful for modifying the inhaled particle deposition and dosimetry models. 20 refs., 9 figs., 1 tab (MHB)

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States)
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 5314824
• Report Number(s): CONF-901010-8; ON: DE91017511
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR FLOW
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
COLLOIDS
DAUGHTER PRODUCTS
DIGESTIVE SYSTEM
DISPERSIONS
DISTRIBUTION
DOSES
EVEN-EVEN NUCLEI
FACE
FLUID FLOW
FUNCTIONAL MODELS
GAS FLOW
HAZARDS
HEAD
HEALTH HAZARDS
HEAVY NUCLEI
INHALATION
INTAKE
ISOTOPES
LOCAL RADIATION EFFECTS
MACACUS
MAMMALS
MONKEYS
NOSE
NUCLEI
ORGANS
PARTICLE SIZE
PHARYNX
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
RADIATION HAZARDS
RADIOACTIVE AEROSOLS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADON 220
RADON ISOTOPES
RESPIRATORY SYSTEM
RESPIRATORY TRACT CELLS
RETENTION
SECONDS LIVING RADIOISOTOPES
SIZE
SOLS
TISSUE DISTRIBUTION
VERTEBRATES