Immunohistochemical study of epoxide hydrolase induced by trichloroethylene in rat liver
Epoxide hydrolase catalyzes the hydrolation of potentially toxic, electrophilic epoxides that are often generated during cytochrome P-450 catalyzed monooxigenation, forming the corresponding transdihydrodiols. It is well-known that trichloroethylene is metabolized by cytochrome P-450 containing mixed-function oxidase systems to trichloroethylene oxide, which decomposes to other metabolites. As trichloroethylene is an epoxide, epoxide hydrolase is suspected to catalyze the hydrolation of trichloroethylene oxide. No reports have appeared about the relationship between trichloroethylene and epoxide hydrolase. In this report, the authors studied the effect of trichloroethylene on epoxide hydrolase immunohistochemically.
- Research Organization:
- Yamaguchi Univ. School of Medicine (Japan)
- OSTI ID:
- 5313135
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 39:4; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
CHEMICAL ACTIVATION
CHEMISTRY
CHLORINATED ALIPHATIC HYDROCARBONS
CYTOCHEMISTRY
CYTOCHROMES
DIGESTIVE SYSTEM
ENZYMES
EPOXIDES
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
HISTOLOGY
HYDROLASES
IMMUNOLOGY
LIVER
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PIGMENTS
PROTEINS
RATS
RODENTS
VERTEBRATES