The natural history of beryllium sensitization and chronic beryllium disease

Journal Article · Tue Oct 01 04:00:00 EDT 1996 · Environmental Health Perspectives

DOI:https://doi.org/10.2307/3433014· OSTI ID:530616

Newman, L S ^[1]; Lloyd, J; Daniloff, E ^[1]

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1. National Jewish Center for Immunology and Respiratory Medicine, Denver, CO (United States)

With the advent of in vitro immunologic testing, we can now detect exposed individuals who are sensitized to beryllium and those who have chronic beryllium disease (CBD) with lung pathology and impairment. Earlier detection and more accurate diagnostic tools raise new questions about the natural history of sensitization and granulomatous disease. Preliminary data suggest that early detection identifies people who are sensitized to beryllium and that these individuals are at risk for progressing into clinical disease. This article discusses the historical, recent, and ongoing studies germane to our understanding of CBD natural history, including the immunologic and inflammatory basis of the disease, the environmental and host risk factors for disease progression, biological markers of disease severity and activity that may help predict outcome, and the implications for broad-based workplace screening to identify patients at the earliest stages of beryllium sensitization and disease. 29 refs., 2 figs.

• Sponsoring Organization: USDOE
• OSTI ID: 530616
• Report Number(s): CONF-9504282--; CNN: Grant ES-00173; Grant ES-04843; Grant R01 ES-04843; Grant HL-27353; Grant M01 RR00051
• Journal Information: Environmental Health Perspectives, Journal Name: Environmental Health Perspectives Journal Issue: Suppl.5 Vol. 104; ISSN 0091-6765; ISSN EVHPAZ
• Country of Publication: United States
• Language: English

Related Subjects

05 NUCLEAR FUELS
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BERYLLIUM
BIOLOGICAL MARKERS
DISEASES
HEALTH HAZARDS
LUNGS
NEOPLASMS
NUCLEAR FACILITIES
OCCUPATIONAL EXPOSURE
RESPIRATORY SYSTEM DISEASES
TOXICITY