Therapeutic dosimetry for Cf-252 neutron brachytherapy of pelvic cancer

Journal Article · Wed May 01 04:00:00 EDT 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90115-4· OSTI ID:5302260

Maruyama, Y; Beach, J L; Hazle, J; Ashtari, M; Schroy, C B; Olson, M H

/sup 252/Cf (Cf) was used to treat tumors of the cervix and uterus with neutron brachytherapy (NT) in an ongoing clinical trial. Tandem and ovoids insertions were used and combinations of single and multiple applications along with high dose whole pelvic irradiation. Dosimetric analysis of treated cases for patterns of tissue dose were carried out. Tissue dose for Cf-NT was, in general, high for neutron components in the central pelvis only, and fell off rapidly with distance from the applicators. The majority and balance of therapeutic dose was contributed by low linear energy transfer (LET) high energy photon beam radiation to the whole pelvis. Comparison with fast neutron beam therapy (NBT) isodose curves showed that much more homogeneous neutron dose was delivered to the pelvic tumor and organs by NBT. Complication frequency has been reported to be higher for neutron beam therapy than for Cf-NT. It appears that the higher integral neutron biological dose to normal tissues for NBT compared to intracavitary Cf-NT probably contributed to the frequency of side effects.

• Research Organization: Univ. of Kentucky, Lexington
• OSTI ID: 5302260
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:5; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLADDER
BODY
BODY AREAS
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
DIGESTIVE SYSTEM
DOSES
DOSIMETRY
ELEMENTARY PARTICLES
ENERGY TRANSFER
EVEN-EVEN NUCLEI
FAST NEUTRONS
FEMALE GENITALS
FERMIONS
FISSION NEUTRONS
GASTROINTESTINAL TRACT
HADRONS
HEAVY NUCLEI
IMPLANTS
INTESTINES
ISODOSE CURVES
ISOTOPES
LARGE INTESTINE
LET
MEDICINE
NEUTRON THERAPY
NEUTRONS
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ORGANS
PATIENTS
PELVIS
RADIATION DOSES
RADIATION EFFECTS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RECTUM
SIDE EFFECTS
THERAPY
URINARY TRACT
USES
UTERUS
YEARS LIVING RADIOISOTOPES