Biliary excretion disorders in infants: evaluation using /sup 99m/Tc PIPIDA

Journal Article · Tue Jul 01 00:00:00 EDT 1980 · Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.135.1.47· OSTI ID:5301907

Miller, J H ^[1]; Sinatra, F R; Thomas, D W

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1. Univ. of Southern California, Los Angeles

A new class of hepatobiliary imaging agents has become available-the N-substituded iminodiacetic acids. After intravenous administration, these compounds are quickly extracted by the hepatocytes and rapidly excreted into the biliary tree. By using a /sup 99m/Tc label, sufficient activity may be given to allow excellent gamma-camera imaging, /sup 99m/Tc-labeled p-isopropylacetanilido-iminodiacetic acid (PIPIDA) has been used in the evaluation of infants with biliary excretion disorders, including two infants with neonatal hepatitis, three with intrahepatic cholestatic jaundice, and 10 with biliary atresia. Follow-up evaluation of surgically created portoenterostomies has been performed as well. In comparison with the previously available agent (/sup 131/I rose bengal), the marked reduction in radiation to the liver alone should predicate the use of /sup 99m/Tc PIPIDA. In addition, the speed of handling of this agent by the liver and the vastly improved imaging statistics make /sup 99m/Tc PIPIDA a desirable agent for the evaluation of biliary excretion disorders in infancy.

• OSTI ID: 5301907
• Journal Information: Am. J. Roentgenol.; (United States), Vol. 135:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ACETIC ACID ESTERS
RADIOPHARMACEUTICALS
BILIARY TRACT
SCINTISCANNING
DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
LIVER
TECHNETIUM 99
COMPARATIVE EVALUATIONS
EXCRETION
HEPATITIS
INFANTS
INTRAVENOUS INJECTION
IODINE 131
ISOMERIC NUCLEI
PATIENTS
ROSE BENGAL
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CHILDREN
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DRUGS
DYES
ESTERS
GLANDS
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
INDICATORS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MAN
NEONATES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PRIMATES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
REAGENTS
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics