Cardiorenal-endocrine dynamics during and following volume expansion

Journal Article · Sun Feb 01 04:00:00 EST 1987 · Am. J. Physiol.; (United States)

OSTI ID:5300886

Zimmerman, R S; Edwards, B S; Schwab, T R; Heublein, D M; Burnett, Jr, J C

The relationship between atrial pressure, atrial natriuretic peptide (ANP), the renin-angiotensin-aldosterone system, and renal hemodynamic and excretory function was examined during and following acute 10% body weight saline volume expansion and measurements were made at 3.3, 6.6, and 10% body weight volume expansion in pentobarbital anesthetized dogs. Right atrial pressure (RAP), pulmonary capillary wedge pressure (PCWP), fractional excretion of Na (FE/sub Na/), and ANP all increased in parallel during volume expansion. Plasma renin activity (PRA) and aldosterone decreased in parallel during 10% volume expansion. ANP, PRA and aldosterone were measured by radioimmunoassay. Following 10% volume expansion, saline was infused at the peak urine flow rate to maintain peak volume expansion. Despite continued saline infusion, RAP, PCWP, and ANP decreased in parallel. In contrast, FE/sub Na/ remained increased, and aldosterone and PRA remained depressed. These studies demonstrate that atrial pressures, ANP, and FE/sub Na/ increase in parallel during volume expansion; this suggests a role for ANP in modulating acute atrial volume overload. During stable volume expansion periods, however, despite a decrease in ANP levels, Na excretion remains elevated, suggesting that non-ANP mechanisms may be important in maintaining natriuresis during stable volume expansion.

• Research Organization: Mayo Medical School, Rochester, MN
• OSTI ID: 5300886
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:2; ISSN AJPHA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ALDEHYDES
ALDOSTERONE
ANGIOTENSIN
ANIMALS
BLOOD PRESSURE
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CLEARANCE
CORTICOSTEROIDS
DOGS
DRUGS
DYNAMIC FUNCTION STUDIES
ENDOCRINE GLANDS
ENZYMES
EXCRETION
GLANDS
GLOBULINS
HOMEOSTASIS
HORMONES
HYDROLASES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
KETONES
KIDNEYS
MAMMALS
MINERALOCORTICOIDS
NONSPECIFIC PEPTIDASES
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
PREGNANES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RENIN
STEROID HORMONES
STEROIDS
TRACER TECHNIQUES
VASOCONSTRICTORS
VERTEBRATES
VOLUME