From 2 Gy to 1 Gy per fraction: sparing effect in rat spinal cord

Journal Article · Mon Feb 01 04:00:00 EST 1988 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(88)90436-1· OSTI ID:5297324

van der Schueren, E; Landuyt, W; Ang, K K; van der Kogel, A J

Recently published results, from this group, on rat cervical spinal cord, a late responding tissue, indicated no further sparing with lowering the fraction size from 2 to 1.8, 1.5, and 1.3 Gy. In the present experiments a small but probably significant rise in tolerance is suggested, when the dose per fraction was decreased from 2 Gy down to 1 Gy. This rise would however still be much less than what is predicted by the linear quadratic model, based on the experimental data obtained with fraction sizes larger than 2 Gy.

• Research Organization: University Hospital St.-Rafal, Leuven (Belgium)
• OSTI ID: 5297324
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 14:2; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
CENTRAL NERVOUS SYSTEM
DOSES
FRACTIONATED IRRADIATION
IRRADIATION
MAMMALS
MATHEMATICAL MODELS
NERVOUS SYSTEM
RADIATION DOSES
RADIOSENSITIVITY
RATS
RODENTS
SPINAL CORD
VERTEBRATES