NMR studies on Pt anti-cancer drug interactions with DNA and related compounds

Thesis/Dissertation · Wed Jan 01 00:00:00 EST 1986

OSTI ID:5281855

Reily, M D

Three metastable species have been identified in the reaction between cisPt(Me/sub 2/SO)/sub 2/Cl/sub 2/ and 7-methyl inosine (7Melno), 7-9-dimethyl hypoxanthine, cytidine (Cyd), 5-methyl cytidine (5-MeCyd), and a series of 2- and 4-substituted pyridines (Xpy) in Me/sub 2/SO. These were cis (I) and trans(Pt(Me/sub 2/SO)(L)Cl/sub 2/) (II), and cis(Pt(Me/sub 2/SO)/sub 2/(L)Cl)Cl(III), where L = N3 or N1 bound C or l derivatives, respectively. cis(Pt(Me/sub 2/SO)(L)/sub 2/Cl)Cl(IV) and l are stable products when r < 0.5(PtL) or r > 0.5, respectively. The /sup 195/Pt NMR spectra of I-IV were recorded for 24 different Xpy. For each of four complexes the dependence of chemical shift on ligand pK/sub a/ was linear for 4Xpy. When 2X was -C = OR (R = H, Me phenyl) downfield shifts of ca. 100 ppm from the 4Xpy pK/sub a/ line were observed.Large upfield shifts were observed when 2X was -NR/sub 2/, R = H or alkyl

• Research Organization: Emory Univ., Atlanta, GA (USA)
• OSTI ID: 5281855
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANTINEOPLASTIC DRUGS
NMR SPECTRA
CHEMICAL SHIFT
COMPLEXES
DNA
MOLECULAR STRUCTURE
NUCLEAR MAGNETIC RESONANCE
PLATINUM
PLATINUM 195
DAYS LIVING RADIOISOTOPES
DRUGS
ELEMENTS
EVEN-ODD NUCLEI
HEAVY NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAGNETIC RESONANCE
METALS
NUCLEI
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PLATINUM ISOTOPES
PLATINUM METALS
RADIOISOTOPES
RESONANCE
SPECTRA
STABLE ISOTOPES
TRANSITION ELEMENTS
550200* - Biochemistry