NMR studies on Pt anti-cancer drug interactions with DNA and related compounds
Thesis/Dissertation
·
OSTI ID:5281855
Three metastable species have been identified in the reaction between cisPt(Me/sub 2/SO)/sub 2/Cl/sub 2/ and 7-methyl inosine (7Melno), 7-9-dimethyl hypoxanthine, cytidine (Cyd), 5-methyl cytidine (5-MeCyd), and a series of 2- and 4-substituted pyridines (Xpy) in Me/sub 2/SO. These were cis (I) and trans(Pt(Me/sub 2/SO)(L)Cl/sub 2/) (II), and cis(Pt(Me/sub 2/SO)/sub 2/(L)Cl)Cl(III), where L = N3 or N1 bound C or l derivatives, respectively. cis(Pt(Me/sub 2/SO)(L)/sub 2/Cl)Cl(IV) and l are stable products when r < 0.5(PtL) or r > 0.5, respectively. The /sup 195/Pt NMR spectra of I-IV were recorded for 24 different Xpy. For each of four complexes the dependence of chemical shift on ligand pK/sub a/ was linear for 4Xpy. When 2X was -C = OR (R = H, Me phenyl) downfield shifts of ca. 100 ppm from the 4Xpy pK/sub a/ line were observed.Large upfield shifts were observed when 2X was -NR/sub 2/, R = H or alkyl
- Research Organization:
- Emory Univ., Atlanta, GA (USA)
- OSTI ID:
- 5281855
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ANTINEOPLASTIC DRUGS
CHEMICAL SHIFT
COMPLEXES
DAYS LIVING RADIOISOTOPES
DNA
DRUGS
ELEMENTS
EVEN-ODD NUCLEI
HEAVY NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAGNETIC RESONANCE
METALS
MOLECULAR STRUCTURE
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
NUCLEI
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PLATINUM
PLATINUM 195
PLATINUM ISOTOPES
PLATINUM METALS
RADIOISOTOPES
RESONANCE
SPECTRA
STABLE ISOTOPES
TRANSITION ELEMENTS
59 BASIC BIOLOGICAL SCIENCES
ANTINEOPLASTIC DRUGS
CHEMICAL SHIFT
COMPLEXES
DAYS LIVING RADIOISOTOPES
DNA
DRUGS
ELEMENTS
EVEN-ODD NUCLEI
HEAVY NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAGNETIC RESONANCE
METALS
MOLECULAR STRUCTURE
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
NUCLEI
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PLATINUM
PLATINUM 195
PLATINUM ISOTOPES
PLATINUM METALS
RADIOISOTOPES
RESONANCE
SPECTRA
STABLE ISOTOPES
TRANSITION ELEMENTS