Role of. pi. -cation radicals in the enzymatic cycles of peroxidases, catalases, and nitrite and sulfite reductases
Conference
·
OSTI ID:5277549
Charge iterative extended Hueckel calculations, and magnetic and optical results on porphyrins, chlorins, and isobacteriochlorins (1) suggest that the catalytic cycles of the enzymes horseradish peroxidase, catalase, Neurospora crassa catalase, and nitrite and sulfite reductases proceed via ..pi..-cation radicals of their prosthetic groups; (2) offer distinguishing features for the optical and magnetic spectra of these radicals, pertinent to their detection as enzymatic intermediates; (3) reconcile the seemingly contradictory optical and NMR data on Compounds I of horseradish peroxidase; and (4) predict that the axial ligation of the heme differs for horseradish peroxidase and catalase.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA); Michigan State Univ., East Lansing (USA). Dept. of Chemistry
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5277549
- Report Number(s):
- BNL-27860; CONF-800490-1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400301 -- Organic Chemistry-- Chemical & Physicochemical Properties-- (-1987)
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
BIOCHEMICAL REACTION KINETICS
CARBOXYLIC ACIDS
CATALYSIS
CATIONS
CHARGED PARTICLES
ENZYMES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IONS
KINETICS
MAGNETIC PROPERTIES
OPTICAL PROPERTIES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PEROXIDASES
PHYSICAL PROPERTIES
PORPHYRINS
RADICALS
REACTION INTERMEDIATES
REACTION KINETICS
400301 -- Organic Chemistry-- Chemical & Physicochemical Properties-- (-1987)
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
BIOCHEMICAL REACTION KINETICS
CARBOXYLIC ACIDS
CATALYSIS
CATIONS
CHARGED PARTICLES
ENZYMES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IONS
KINETICS
MAGNETIC PROPERTIES
OPTICAL PROPERTIES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PEROXIDASES
PHYSICAL PROPERTIES
PORPHYRINS
RADICALS
REACTION INTERMEDIATES
REACTION KINETICS