Binding of B(a)P diol epoxide to chromosomal histone proteins

Conference · Mon Jan 01 04:00:00 EST 1979

OSTI ID:5277460

Kootstra, A.; Cronen, M. C.; Slaga, T. J.

In order to understand how a chemical such as benzo(a)pyrene (B(a)P) exerts its carcinogenic effect, a fundamental knowledge is required concerning the interaction of metabolites of B(a)P with the macromolecules of the eukaryotic cell and the consequences of such interaction at the molecular level. Since current evidence suggests that the DNA is an important target of the ultimate carcinogenic form of B(a)P, the B(a)P diol epoxide, we have studied the binding of B(a)P diol epoxide (anti) to chromatin in vitro, in order to obtain some information about the interaction of this carcinogen with the various components of chromatin.

• Research Organization: Tennessee Univ., Oak Ridge (USA). Graduate School of Biomedical Sciences; Oak Ridge National Lab., TN (USA)
• Sponsoring Organization: USDOE Office of Health and Environmental Research
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5277460
• Report Number(s): CONF-791059--7
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AROMATICS
BENZOPYRENE
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL BONDS
CHEMISTRY
CHROMATIN
CONDENSED AROMATICS
DATA
EPOXIDES
ERYTHROCYTES
EXPERIMENTAL DATA
HISTONES
HYDROCARBONS
IN VITRO
INFORMATION
LABELLING
MATERIALS
MOLECULAR STRUCTURE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PROTEINS