Harvard-MIT research program in short-lived radiopharmaceuticals. Progress report, March 1, 1983-February 29, 1984

Technical Report · Tue Jan 31 23:00:00 EST 1984

OSTI ID:5276181

Adelstein, S J; Brownell, G L

This report describes research efforts towards the achievement of a clearer understanding of the solution chemistry of technetium in order to facilitate the design of future clinical agents labeled with Tc-99m, the development of new receptor binding radiopharmaceuticals for the in vivo assessment of insulin receptors and for imaging the adrenal medulla and the brain, the examination of the utility of monoclonal antibodies and liposomes in the design of radiopharmaceuticals for diagnosis and therapy, and the synthesis of short-lived positron-emitting radiopharmaceuticals for transverse imaging of regional physiological processes.

• Research Organization: Massachusetts Inst. of Tech., Cambridge (USA)
• DOE Contract Number: AC02-76EV04115
• OSTI ID: 5276181
• Report Number(s): DOE/EV/04115-T5; ON: DE84006657
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550101 -- Behavioral Biology-- Tracer Techniques
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
AMINO ACIDS
ANALEPTICS
ANIMAL CELLS
ANIMALS
ANTIBODIES
AROMATICS
ARYL RADICALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBON ISOTOPES
CARBOXYLIC ACIDS
CARCINOMAS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHEMICAL PREPARATION
CHEMICAL REACTION KINETICS
CHEMISTRY
CHROMATOGRAPHY
COMPUTERIZED TOMOGRAPHY
CONDENSED AROMATICS
COUNTING TECHNIQUES
DATA
DAYS LIVING RADIOISOTOPES
DEVELOPERS
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DOPA
DOPAMINE
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ESTRADIOL
ESTRANES
ESTROGENS
EVEN-ODD NUCLEI
FEMALE GENITALS
FLUORINE ISOTOPES
GLANDS
HEART
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
HORMONES
HOURS LIVING RADIOISOTOPES
HYBRIDOMAS
HYDROXY ACIDS
HYDROXY COMPOUNDS
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LABELLING
LEUKEMIA
LIGHT NUCLEI
LIPOSOMES
LIPOTROPIC FACTORS
LIQUID COLUMN CHROMATOGRAPHY
MAGNETIC RESONANCE
MALE GENITALS
MAMMALS
METHIONINE
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
MUSCLES
MYELOID LEUKEMIA
NEOPLASMS
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOIDS
ORGANS
PHENETHYL RADICALS
PHENOLS
PIPERAZINES
POLYPHENOLS
PRIMATES
PROSTATE
PYRAZINES
RADICALS
RADIOASSAY
RADIOISOTOPE SCANNING
RADIOISOTOPES
REACTION KINETICS
RECEPTORS
RESONANCE
RODENTS
SEPARATION PROCESSES
STEROID HORMONES
STEROIDS
SYMPATHOMIMETICS
SYNTHESIS
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
TOMOGRAPHY
TRACER TECHNIQUES
TRANSITION ELEMENT COMPOUNDS
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES