Protection of intestinal damage by pretreatment with cytarabine (cytosine arabinoside)
The circumstances in which cytarabine (cytosine arabinoside) ''protects'' intestinal epithelial stem cells against radiation have been investigated. Special attention has been given to this protective effect with radiation doses in the clinically used range in order to determine whether the protective effect might be of use in radiotherapy. It has been shown that 12 hours after cytarabine the D/sub 0/ and extrapolation number are increased when large single doses of radiation are used. To determine the effect of cytarabine at lower doses, it is necessary to use a second irradiation as an ''assay'' dose. By this means it is shown that there is more protection than can be accounted for by the change in D/sub 0/ and extrapolation number at the time of the first dose. Evidence is presented indicating that the rate of stem cell regeneration is not increased by cytarabine pretreatment. Finally, the relation between intestinal protection, bone marrow stem cell enhanced recovery and improved animal survival as a result of cytarabine pretreatment is discussed.
- Research Organization:
- Inst. of Cancer Research, Surrey, England
- OSTI ID:
- 5276115
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 5:9; Conference: Conference on combined modalities: chemotherapy/radiotherapy. Part 2, Hilton Head Island, SC, USA, 15 Nov 1978
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL RECOVERY
BIOLOGICAL RADIATION EFFECTS
BONE MARROW CELLS
CLONE CELLS
GAMMA RADIATION
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
STEM CELLS
RADIATION PROTECTION
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
ISOLATED VALUES
RADIATION DOSES
SURVIVAL CURVES
TIME DEPENDENCE
WHOLE-BODY IRRADIATION
ANIMAL CELLS
BIOLOGICAL EFFECTS
CELL CULTURES
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RECOVERY
RESPONSE MODIFYING FACTORS
SOMATIC CELLS
560121* - Radiation Effects on Cells- External Source- (-1987)
550603 - Medicine- External Radiation in Therapy- (1980-)