Dose-time relationships for post-irradiation cutaneous telangiectasia
Seventy-five patients who had received electron beam radiation a year or more previously were studied. The irradiated skin portals were photographed and late reactions graded in terms of the number and severity of telangiectatic lesions observed. The skin dose, number of fractions, overall treatment time and irradiated volume were recorded in each case. A Strandqvist-type iso-effect line was derived for this response. A multi-probit search program also was used to derive best-fitting cell population kinetic parameters for the same data. From these parameters a comprehensive iso-effect table could be computed for a wide range of treatment schedules including daily treatment as well as fractionation at shorter and longer intervals; this provided a useful set of normal tissue tolerance limits for late effects.
- Research Organization:
- Michael Reese Medical Center, Chicago
- OSTI ID:
- 5276081
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 2:5/6
- Country of Publication:
- United States
- Language:
- English
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RADIOTHERAPY
SIDE EFFECTS
SKIN
RADIATION INJURIES
ELECTRON BEAMS
FRACTIONATED IRRADIATION
PATIENTS
TEMPORAL DOSE DISTRIBUTIONS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
INJURIES
IRRADIATION
LEPTON BEAMS
MEDICINE
NUCLEAR MEDICINE
ORGANS
PARTICLE BEAMS
RADIATION DOSE DISTRIBUTIONS
RADIATION EFFECTS
RADIOLOGY
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560151* - Radiation Effects on Animals- Man