Effects of bipenst and dimethylsulfoxide on adenylic nucleotide content of liver of irradiated animals. [Rats, x radiation]
Experiments were conducted on the following groups of rats: nonirradiated control; nonirradiated rats given Bipenst intramuscularly; nonirradiated rats given DMSO intramuscularly; irradiated control; irradiated rats given Bipenst and DMSO for 8 days. The animals were killed and the liver nucleotides ATP, ADP, and AMP were assayed by electrophoresis followed by spectrophotometry. Levels of nucleotides in nonirradiated animals were not appreciably changed by the drugs. In irradiated animals there was an elevation of ATP and ADP under the influence of Bipenst and DMSO. There was no change in the AMP level. Clinical data indicate that regenerative processes increase under the influence of these agents in laryngectomized patients who had received radiotherapy. (HLW)
- Research Organization:
- Kiev Medical Inst.
- OSTI ID:
- 5275891
- Journal Information:
- Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 17:2; ISSN RADBA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADP
AMP
ANIMALS
ATP
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
DMSO
DRUGS
ELECTROMAGNETIC RADIATION
GLANDS
IONIZING RADIATIONS
LIVER
MAMMALS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SULFOXIDES
VERTEBRATES
X RADIATION