Carbon monoxide kinetics following simulated cigarette smoking

Journal Article · Thu May 01 04:00:00 EDT 1980 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1980.10667482· OSTI ID:5274495

Karnik, A S ^[1]; Coin, E J

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1. Wayne State Univ., Detroit, MI

Carbon monoxide kinetics were measured in the blood (% carboxyhemoglobin) and alveolar phase (ppM carbon monoxide) after simulated cigarette smoking. Cigarette smoking was siumlated using the same amount of carbon monoxide that 2R1F cigarettes manufactured by the Tobacco Research Institute would contain. Ten boluses of air containing carbon monoxide equivalent to smoking one cigarette were inhaled by six healthy nonsmoker volunteers. Carbon monoxide in the air phase was measured by an Ecolyzer and carboxyhemoglobin was measured by a CO-Oximeter. The mean rise in alveolar carbon monoxide immediately and 20 min after inhaling the last bolus was 3.3 and 3.1 ppM, respectively (p<.005). The mean rise in carboxyhemoglobin immediately and 20 min after inhalation of the last bolus was 0.8 and 0.5% respectively (P<.005). The changes in carboxyhemoglobin were found to be similar to changes that occur when one cigarette is actually smoked.

• OSTI ID: 5274495
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 35:3; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism &amp; Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CARBOXYHEMOGLOBIN
CHALCOGENIDES
COLLOIDS
DISPERSIONS
INHALATION
INTAKE
KINETICS
MATERIALS
OXIDES
OXYGEN COMPOUNDS
REACTION KINETICS
RESIDUES
SIMULATION
SMOKES
SOLS
TOBACCO PRODUCTS
TOBACCO SMOKES