Insulin-like growth factor I enhances proenkephalin synthesis and dopamine. beta. -hydroxylase activity in adrenal chromaffin cells
Journal Article
·
· Life Sciences; (United States)
- Univ. of South Carolina School of Medicine, Columbia (USA)
Insulin-like growth factor I (IGF-I) increased both the contents of proenkephalin derived enkephalin-containing peptides and the activity of dopamine {beta}-hydroxylase in bovine adrenal chromaffin cells. These increases in dopamine {beta}-hydroxylase and enkephalin-containing peptides continued for at least 8 days. The half-maximal IGF-I concentration for these effects was {approximately} 1 nM, with maximal effects observed at 10-30 nM. In contrast, insulin was 1,000-fold less potent. Pretreatment of chromaffin cells with IGF-I increased the rate of ({sup 35}S)proenkephalin synthesis 4-fold compared to untreated cells. Total protein synthesis increased only 1.5-fold under these conditions. These results suggest that IGF-I may be a normal regulator of chromaffin cell function.
- OSTI ID:
- 5272356
- Journal Information:
- Life Sciences; (United States), Journal Name: Life Sciences; (United States) Vol. 49:4; ISSN 0024-3205; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL GLANDS
AMINES
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOSYNTHESIS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CATTLE
DAYS LIVING RADIOISOTOPES
DOMESTIC ANIMALS
DOPAMINE
DRUGS
ENDOCRINE GLANDS
ENDORPHINS
ENKEPHALINS
ENZYME ACTIVITY
ENZYMES
EVEN-ODD NUCLEI
GLANDS
GROWTH FACTORS
HORMONES
HYDROXY COMPOUNDS
HYDROXYLASES
INSULIN
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
MAMMALS
MITOGENS
NEUROREGULATORS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEPTIDE HORMONES
PEPTIDES
PHENOLS
POLYPEPTIDES
POLYPHENOLS
PROTEINS
RADIOISOTOPES
REACTION KINETICS
RUMINANTS
SULFUR 35
SULFUR ISOTOPES
SYMPATHOMIMETICS
SYNTHESIS
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ADRENAL GLANDS
AMINES
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOSYNTHESIS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CATTLE
DAYS LIVING RADIOISOTOPES
DOMESTIC ANIMALS
DOPAMINE
DRUGS
ENDOCRINE GLANDS
ENDORPHINS
ENKEPHALINS
ENZYME ACTIVITY
ENZYMES
EVEN-ODD NUCLEI
GLANDS
GROWTH FACTORS
HORMONES
HYDROXY COMPOUNDS
HYDROXYLASES
INSULIN
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
MAMMALS
MITOGENS
NEUROREGULATORS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEPTIDE HORMONES
PEPTIDES
PHENOLS
POLYPEPTIDES
POLYPHENOLS
PROTEINS
RADIOISOTOPES
REACTION KINETICS
RUMINANTS
SULFUR 35
SULFUR ISOTOPES
SYMPATHOMIMETICS
SYNTHESIS
TRACER TECHNIQUES
VERTEBRATES