Effect of urokinase on the proliferation of primary cultures of human prostatic cells
Journal Article
·
· Thromb. Res.; (United States)
The effects of exogenously added urokinase type plasminogen activator, tissue type plasminogen activator, plasmin and thrombin on the proliferation of primary cultures of cells derived from prostatic hyperplasia or prostatic carcinomas were investigated by measuring the incorporation of /sup 3/H-thymidine into the cultures. Addition of urokinase type plasminogen activator (1.35 x 10(-9) M) or thrombin (10(-7) M) to the culture medium caused a two-fold increase of /sup 3/H-thymidine incorporation, regardless of the origin of the prostatic cells. Tissue type plasminogen activator did not alter the rate of /sup 3/H-thymidine incorporation, whereas plasmin caused a 25% decrease of /sup 3/H-thymidine incorporation in all cultures.
- Research Organization:
- Univ. of Vienna (Austria)
- OSTI ID:
- 5272116
- Journal Information:
- Thromb. Res.; (United States), Journal Name: Thromb. Res.; (United States) Vol. 48:3; ISSN THBRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
AZINES
BIOCHEMICAL REACTION KINETICS
BODY
CELL PROLIFERATION
COAGULANTS
DISEASES
DNA REPLICATION
DRUGS
ENZYMES
FIBRINOLYSIN
FIBRINOLYTIC AGENTS
GLANDS
HEMATOLOGIC AGENTS
HEMOSTATICS
HETEROCYCLIC COMPOUNDS
HYDROLASES
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MALE GENITALS
NEOPLASMS
NONSPECIFIC PEPTIDASES
NUCLEIC ACID REPLICATION
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
PROSTATE
PYRIMIDINES
REACTION KINETICS
RIBOSIDES
SERINE PROTEINASES
THROMBIN
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
UROKINASE
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
AZINES
BIOCHEMICAL REACTION KINETICS
BODY
CELL PROLIFERATION
COAGULANTS
DISEASES
DNA REPLICATION
DRUGS
ENZYMES
FIBRINOLYSIN
FIBRINOLYTIC AGENTS
GLANDS
HEMATOLOGIC AGENTS
HEMOSTATICS
HETEROCYCLIC COMPOUNDS
HYDROLASES
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MALE GENITALS
NEOPLASMS
NONSPECIFIC PEPTIDASES
NUCLEIC ACID REPLICATION
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
PROSTATE
PYRIMIDINES
REACTION KINETICS
RIBOSIDES
SERINE PROTEINASES
THROMBIN
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
UROKINASE