Radiochemical purity and in vitro stability of commercial hippurans
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5271009
Good radiochemical purity of hippuran is important regarding the patient's radiation dose, primarily because of the high thyroid exposure from free iodide. The radiochemical purity and in vitro stability of 11 commercially available /sup 131/I, /sup 125/I, and /sup 123/I hippurans were analyzed by means of thin layer chromatography. Three different radioactive impurities were found in all hippuran samples: (a) free radioiodide, (b) a radiochemical impurity that has been unknown up until now, and (c) labeled o-iodobenzoic acid. Quality control of several hippurans with regard to radiochemical purity gave evidence of considerable differences during storage. The lowest amount of free-iodide was 0-0.6% in a hippuran preparation from one manufacturer, the highest amount 0.8-4.6% in a sample from another manufacturer. Hippuran samples from four other manufacturers were found to contain greater than 2% of free iodide prior to their expiration date.
- Research Organization:
- Institute for Radiation Hygiene, Neuherberg, Germany, F.R.
- OSTI ID:
- 5271009
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 6; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHEMISTRY
CONTRAST MEDIA
CONTROL
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HIPPURAN
HOURS LIVING RADIOISOTOPES
IMPURITIES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE 125
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
QUALITY CONTROL
RADIOCHEMISTRY
RADIOISOTOPES
RADIOPHARMACEUTICALS
STABILITY
THYROID
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHEMISTRY
CONTRAST MEDIA
CONTROL
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HIPPURAN
HOURS LIVING RADIOISOTOPES
IMPURITIES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE 125
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
QUALITY CONTROL
RADIOCHEMISTRY
RADIOISOTOPES
RADIOPHARMACEUTICALS
STABILITY
THYROID