Comparison of generator-produced radionuclides for cerebral positron emission tomography applications

Conference · Fri Nov 01 04:00:00 EST 1985 · Trans. Am. Nucl. Soc.; (United States)

OSTI ID:5270083

Mathis, C A

The production of short-lived positron-emitting radionuclides by small portable generators can reduce the prohibitive costs of purchasing and running a dedicated medical cyclotron for positron emission tomography (PET) studies. Several generator systems are available for PET applications, but these systems have had limited success in studying cerebral function. Assessment of blood-brain barrier (BBB) integrity has been made with the /sup 82/Sr//sup 82/Rb and /sup 68/Ge//sup 68/Ga generator systems, but determination of regional cerebral blood flow (rCBF) and regional cerebral blood volume (rCBV) utilizing these generators has been limited. The potential usefulness of the /sup 122/X//sup 122/I generator system for brain PET studies is being explored by the Donner Research Medicine Group. The physical properties of the parent and daughter radionuclides are shown. The decay properties of the daughters are important in considering the dose to the patient per millicurie injected and the imaging characteristics in the PET camera. A longer half-life is more convenient to the radiochemist in the preparation and handling of the radiopharmaceutical, but this results in a higher patient dose and the inability to perform serial studies in the patient over a short time period. The properties of the various generators are further compared with respect to specific cerebral applications below.

• Research Organization: Lawrence Berkeley Lab., CA
• OSTI ID: 5270083
• Report Number(s): CONF-851115-
• Conference Information: Journal Name: Trans. Am. Nucl. Soc.; (United States) Journal Volume: 50
• Country of Publication: United States
• Language: English

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