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Effects of phenobarbital pretreatment on the in vivo metabolism of carbaryl in rats

Journal Article · · Bull. Environ. Contam. Toxicol.; (United States)
DOI:https://doi.org/10.1007/BF01855860· OSTI ID:5269847
; ;
Phenobarbital (PB) pretreatment of animals is known to induce the activity of drug-metabolizing enzymes in liver microsomes. Previous studies showed that incubation of carbaryl with microsomes obtained from livers of untreated or PB-treated rats resulted in little or no oxidative metabolism of the substrate. In addition, no spectral interactions were observed when carbaryl was added to hepatic microsomal suspensions. The present study was carried out to determine the effect of PB pretreatment on the in vivo metabolism of carbaryl in rats.
Research Organization:
Uniformed Services Univ., Bethesda, MD (USA)
OSTI ID:
5269847
Journal Information:
Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 39:5; ISSN BECTA
Country of Publication:
United States
Language:
English

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Related Subjects

550201 -- Biochemistry-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANESTHETICS
ANIMALS
ANTICONVULSANTS
AZINES
BARBITURATES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBAMATES
CARBON 14 COMPOUNDS
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHROMATOGRAPHY
CLEARANCE
DRUGS
ENZYME INDUCTION
EXCRETION
GENE REGULATION
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
IN VIVO
INJECTION
INSECTICIDES
INTAKE
INTRAPERITONEAL INJECTION
ION EXCHANGE CHROMATOGRAPHY
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLISM
METABOLITES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PESTICIDES
PHENOBARBITAL
PYRIMIDINES
RATS
RODENTS
SEPARATION PROCESSES
URINE
VERTEBRATES
WASTES