Demonstration of clonable alloreactive host T cells in a primate model for bone marrow transplantation

Journal Article · Sun Jun 01 04:00:00 EDT 1986 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.83.11.4012· OSTI ID:5268962

Reisner, Y; Ben-Bassat, I; Douer, D; Kaploon, A; Schwartz, E; Ramot, B

The phenomenon of marrow rejection following supralethal radiochemotherapy was explained in the past mainly by non-T-cell mechanisms known to be resistant to high-dose irradiation. In the present study a low but significant number of radiochemoresistant-clonable T cells was found in the peripheral blood and spleen of Rhesus monkeys following the cytoreductive protocol used for treatment of leukemia patients prior to bone marrow transplantation. More than 95% of the clonable cells are concentrated in the spleen 5 days after transplant. The cells possess immune memory as demonstrated by the generation of alloreactive-specific cytotoxicity. The present findings suggest that host-versus-graft activity may be mediated by alloreactive T cells. It is hoped that elimination of such cells prior to bone marrow transplantation will increase the engraftment rate of HLA-nonidentical marrow in leukemia patients.

• Research Organization: Weizmann Institute of Science, Rehovot, Israel
• OSTI ID: 5268962
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 11; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW
CELL CULTURES
CELL CYCLE
CLONE CELLS
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
IMMUNOSUPPRESSION
LYMPH NODES
LYMPHATIC SYSTEM
MACACUS
MAMMALS
MEDICINE
MONKEYS
NUCLEAR MEDICINE
ORGANS
PRIMATES
RADIOLOGY
RADIOTHERAPY
SOMATIC CELLS
SPLEEN CELLS
THERAPY
TISSUES
TRANSPLANTS
VERTEBRATES