Life style and occupational risk factors for bladder cancer in Germany. A case-control study

Journal Article · Wed Apr 01 04:00:00 EST 1992 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19920401)69:7<1776::AID-CNCR2820690721>3.0.CO;2-P· OSTI ID:5267069

Kunze, E; Chang-Claude, J; Frentzel-Beyme, R ^[1]

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1. Department of Pathology, University of Goettingen, (Germany)

A hospital-based, case-control study of 531 male and 144 female matched pairs was conducted in Germany to analyze the role of nonoccupational and occupational risk factors in the etiology of tumors of the lower urinary tract (bladder cancer). Smoking of cigarettes was associated with an odds ratio (OR) of 3.6 for men and 3.2 for women, compared with not smoking and showed a significant dose- and time-response relationship for both sexes. Heavy pipe smoking significantly increased the risk (OR = 1.9 in men), and smoking of cigars did not alter the risk of bladder cancer. Controlling for smoking, a significantly twofold or more increase in risk was found for heavy consumption of coffee in both sexes and for heavy intake of beer in males. Increasing levels of total fluid intake were associated with increasing, smoking-adjusted risks in men. Significant associations were found for chronic infection of the lower urinary tract (OR = 1.8), familial history of bladder cancer (OR = 2.5), and frequent consumption of high fat meals (OR = 1.4) among men and for frequent consumption of canned food in both sexes. With regard to occupational history, significantly elevated odds ratios were found for ever-employment in the printing (5.0), plastics and synthetics (2.6), rubber (2.5), mining (2.0), and dyestuffs (1.9) industries, for exposure to spray paints (2.9), zinc (2.3), chromium/chromate (2.2), oils (1.5), petroleum (1.4), stone dust (1.4) and metal dust/fumes (1.3), and for occupation as mining worker (2.0) and truck driver (1.8) among men. Multivariate logistic regression analysis showed significant contribution of coffee and beer drinking, ingestion of canned food, and familial occurrence of urothelial tumors to the risk of bladder cancer in men after accounting for the effects of tobacco smoking, occupational exposures, and a history of bladder infection.

• OSTI ID: 5267069
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 69:7; ISSN 0008-543X; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism &amp; Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BLADDER
BODY
CARCINOGENESIS
CHROMIUM
COATINGS
COLLOIDS
DISEASES
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
DYES
ELEMENTS
ENERGY SOURCES
ETIOLOGY
FOSSIL FUELS
FUELS
GERMANY
INDUSTRY
MAMMALS
MAN
MATHEMATICS
METALS
MINING
MULTIVARIATE ANALYSIS
NEOPLASMS
OCCUPATIONAL EXPOSURE
OILS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PAINTS
PATHOGENESIS
PETROLEUM
PLASTICS INDUSTRY
PRIMATES
PRINTING AND PUBLISHING INDUSTRY
REGRESSION ANALYSIS
RESIDUES
RISK ASSESSMENT
RUBBER INDUSTRY
SMOKES
SOLS
STATISTICS
TOBACCO SMOKES
TRANSITION ELEMENTS
URINARY TRACT
UROGENITAL SYSTEM DISEASES
VERTEBRATES
ZINC