Technetium-99m glucoheptonate as a brain-scanning agent

Journal Article · Sat Oct 01 04:00:00 EDT 1977 · J. Nucl. Med.; (United States)

OSTI ID:5265261

Tanesescu, D E; Wolfstein, R S; Waxman, A D

Of importance is proposed mechanism that TcGH functions as a substrate for the highly metabolic brain tumor tissue, which results in an enhanced lesion uptake. Significant concentration of Tc chelates in lesions may be related in part to the increased metabolic activity of abnormal tissue. Mechanisms such as enhanced blood clearance, effective penetration of the blood/brain barrier, tissue binding, and other factors, however, must be considered. We have recently analyzed 800 consecutive brain scans using TcGH, and have found the tumor detection rate to be 94%. The detection rate for infarction was slightly greater than 50% within the first week after insult, and increased to 75% after the first week. When a flow study was included, the detection rate for all infarcts was further increased to 90% for the detection of brain tumors TcGH offers certain advantages over TcO/sub 4//sup -/.

• Research Organization: Cedars-Sinai Medical Center, Los Angeles
• OSTI ID: 5265261
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 18:10; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHELATES
COMPLEXES
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES