PET measurements of hyperthermia-induced suppression of protein synthesis in tumors in relation to effects on tumor growth
- University Hospital, Groningen (Netherlands)
Hyperthermia-induced metabolic changes in tumor tissue have been monitored by PET. Uptake of L-(1-11C)tyrosine in rhabdomyosarcoma tissue of Wag/Rij rats was dose-dependently reduced after local hyperthermia treatment at 42, 45, or 47 degrees C. Tumor blood flow, as measured by PET with 13NH3, appeared to be unchanged. The L-(1-11C)tyrosine uptake data were compared to uptake data of L-(1-14C)tyrosine and with data on the incorporation of L-(1-14C)tyrosine into tumor proteins. After intravenous injection, the 14C data were obtained from dissected tumor tissue. Heat-induced inhibition of the incorporation of L-(1-14C)tyrosine into tumor proteins tallied with the L-(1-11C)tyrosine uptake data. Heat-induced inhibition of amino acid uptake in the tumor correlated well with regression of tumor growth. It is concluded that PET using L-(1-11C)tyrosine is eligible for monitoring the effect of hyperthermia on tumor growth.
- OSTI ID:
- 5265183
- Journal Information:
- Journal of Nuclear Medicine; (United States), Journal Name: Journal of Nuclear Medicine; (United States) Vol. 32:8; ISSN 0161-5505; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
AMMONIA
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY TEMPERATURE
CARBON 11
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CARBON ISOTOPES
CARBOXYLIC ACIDS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
EXPERIMENTAL NEOPLASMS
GROWTH
HYDRIDES
HYDROGEN COMPOUNDS
HYDROXY ACIDS
HYPERTHERMIA
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
POSITRON COMPUTED TOMOGRAPHY
PROTEINS
RADIOISOTOPES
RATS
RODENTS
SYNTHESIS
TOMOGRAPHY
TYROSINE
VERTEBRATES